Concepedia

Antagonistic effect of the cardioprotector (+)-1,2-BIS(3,5-dioxopiperazinyl-1-YL)propane(ICRF-187) on dna breaks and cytotoxicity induced by the topoisomerase ii directed drugs daunorubicin and etoposide (VP-16)

Maxwell Sehested, Peter Buhl Jensen, Boe Sandahl Sørensen, Bente Holm, Ellen Friche, Erland J.F. Demant

Biochemical Pharmacology · 1993 · 91 citations · 20 references

DOI

Concepts

References

20

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science · 1984 · 1.5K citations

, , +16

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer.

James L. Speyer, M D Green, Anne Zeleniuch‐Jacquotte et al. · Journal of Clinical Oncology · 1992 · 323 citations

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

K Tanabe, Yoji Ikegami, Ryoji Ishida et al. · PubMed · 1991 · 297 citations

, , +14

Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors.

Ryoji Ishida, T Miki, Toshiharu Narita et al. · PubMed · 1991 · 195 citations

, , +23

In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.

F H Drake, G A Hofmann, Shau Ming Mong et al. · PubMed · 1989 · 160 citations

, , +19