Antagonistic effect of the cardioprotector (+)-1,2-BIS(3,5-dioxopiperazinyl-1-YL)propane(ICRF-187) on dna breaks and cytotoxicity induced by the topoisomerase ii directed drugs daunorubicin and etoposide (VP-16)

Maxwell Sehested, Peter Buhl Jensen, Boe Sandahl Sørensen, +3

Biochemical Pharmacology

BiochemistryTopoisomerase IiMedicineMechanism Of ActionAntagonistic Effect +7

Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.

Mary K. Danks, MARYANNA WARMOTH, Ellen Friche, +7

PubMed

Molecular BiologyAmino Acid 802Amino Acid ChangeTumor BiologyDrug Resistance +15

The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.

Ellen Friche, Jensen Pb, Maxwell Sehested, +2

PubMed

Multidrug Resistant EhrlichMedicinal ChemistryPlasma Membrane VesiclesPharmaceutical ScienceTween 80 +13

Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.

Ellen Friche, Mary K. Danks, Carla Schmidt, +1

PubMed

Reductive StressOncogenic AgentTopoisomerase IiMedicinePharmacology +11

Different modes of anthracycline interaction with topoisomerase II

Peter Buhl Jensen, Boe Sandahl Sørensen, Maxwell Sehested, +4

Biochemical Pharmacology

BiochemistryDifferent ModesNatural SciencesAnti-cancer AgentChemical Biology +1

Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.

Peter Bjødstrup Jensen, Palle S. Jensen, Erland J.F. Demant, +7

PubMed

PathologyCell DeathMdr ModulatorMdr Modulator VerapamilCancer Biology +15

Comparison of cyclosporin A and SDZ PSC833 as multidrug-resistance modulators in a daunorubicin-resistant Ehrlich ascites tumor

Ellen Friche, Peter Buhl Jensen, Nis I. Nissen

Cancer Chemotherapy and Pharmacology

BiochemistryMedicineMechanism Of ActionCyclosporin APharmacotherapy +9

Relationship of VP-16 to the classical multidrug resistance phenotype.

Maxwell Sehested, Ellen Friche, P B Jensen, +1

PubMed

PharmacotherapyAntibiotic ResistanceExperimental PharmacologyCellular PhysiologyDrug Resistance +14

Effect of verapamil on daunorubicin accumulation in Ehrlich ascites tumor cells

Ellen Friche, Torben Skovsgaard, Nis I. Nissen

Cancer Chemotherapy and Pharmacology

BiochemistryMedicineTumor CellsDaunorubicin AccumulationPharmacology +3

Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells

Maxwell Sehested, Torben Skovsgaard, Peter Buhl Jensen, +3

British Journal of Cancer

BiochemistryWild TypeMedicineMechanism Of ActionMultidrug Resistance Modulators +6