DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed, +10

Nature

ChromatinTumor BiologyGenome InstabilityDna DamageOncogenic Agent +9

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos, +22

Nature

Oncogene-induced SenescenceChromatinGenome InstabilityDna DamageOncogenic Agent +9

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Nagma Khan, Michael Jeffers, Sampath Kumar, +14

Biochemical Journal

Histone ModificationsClass IiSpecific IsoformsChemoprevention StrategyPathology +18

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Randi G. Syljuåsen, Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, +7

Molecular and Cellular Biology

ChromatinGenome InstabilityHuman Chk1 CausesDna BreakageCell Regulation +9

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.

Boye Schnack Nielsen, Niels Borregaard, Jens R. Bundgaard, +3

Gut

ImmunologyGastroenterologyPathologyNgal SynthesisInflammatory Bowel Diseases +16

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

Richard A. DiTullio, Tamara A. Mochan, Monica Venere, +4

Nature Cell Biology

OncologyMedicineCell DeathCancer Cell BiologyHuman Cancer +8

Neutrophil Gelatinase-Associated Lipocalin Is Up-Regulated in Human Epithelial Cells by IL-1β, but Not by TNF-α

Jack B. Cowland, Ole E. Sørensen, Maxwell Sehested, +1

The Journal of Immunology

Inflammatory Lung DiseaseLung InflammationImmunologyImmune RegulationNeutrophil Gelatinase-associated Lipocalin +19

Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases

Maxwell Sehested, K Hou-Jensen

Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin

InflammationImmunologyHematologyPathologyHistopathology +7

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

Niels Borregaard, Maxwell Sehested, BS Nielsen, +1

Blood

Quantitative Proteomic Analysis of Post-translational Modifications of Human Histones

Hans Christian Beck, Eva C. Nielsen, Rune Matthiesen, +6

Molecular & Cellular Proteomics

Histone ModificationsEpigenetic ChangeBiological Mass SpectrometryMolecular BiologyQuantitative Proteomic Analysis +18