Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors.

Ryoji Ishida, T Miki, Toshiharu Narita, +5

PubMed

Chemoprevention StrategyAntitumor BisIntracellular Topoisomerase IiPharmacotherapyCell Cycle +21

Hypotensive Constituent, Kuwaman H, a New Flavone Derivative from the Root Bark of the Cultivated Mylberry Tree (Morus alba L.)

Taro Nomura, Toshio Fukai, Toshiharu Narita

Heterocycles

Bioorganic ChemistryBiochemistryBotanyNatural SciencesCultivated Mulberry Tree +9

Confirmation of the structures of kuwanons G and H (albanins F and G) by partial synthesis

Taro Nomura, Toshio Fukai, Toshiharu Narita, +7

Tetrahedron Letters

BiosynthesisBioorganic ChemistryPartial SynthesisBiochemistryEngineering +4

Antitumor active glycosides from Condurango Cortex.

Kôji Hayashi, Keiji Wãda, Hiroshi Mitsuhashi, +7

Chemical and Pharmaceutical Bulletin

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural Sciences +10

Antitumor activities and schedule dependence of orally administered MST-16, a novel derivative of bis(2,6-dioxopiperazine)

Toshiharu Narita, Yuji Koide, Shin‐ichi Yaguchi, +5

Cancer Chemotherapy and Pharmacology

Medicinal ChemistrySchedule DependenceMedicinePharmacologyPharmacotherapy +7

Antitumor activity of MST-16, a novel derivative of bis(2,6-dioxopiperazine), in murine tumor models

Toshiharu Narita, Shin‐ichi Yaguchi, Toshihiko Komatsu, +4

Cancer Chemotherapy and Pharmacology

Medicinal ChemistryAntitumor ActivityChemoprevention StrategyNovel DerivativeMedicine +8

Further investigation of antitumor condurangoglycosides with C-18 oxygenated aglycone.

Kôji Hayashi, Keiji Wãda, Hiroshi Mitsuhashi, +7

Chemical and Pharmaceutical Bulletin

Medicinal ChemistryPharmaceutical ScienceBiochemistryAntitumor Active Condurangoglycosides-b0Medicine +11

Synthesis and antitumor properties of N1-acyloxymethyl derivatives of bis(2,6-dioxopiperazines).

Jun Cai, H. L. Shu, Cai Fang TANG, +6

Chemical and Pharmaceutical Bulletin

Antiallergic substance from Asarum sagittarioides and synthesis of some analogues.

Sumio Terada, TAKU MOTOMIYA, Kimitomo Yoshioka, +3

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryAntiparasitic AgentPharmacotherapyMeoh ExtractChemistry +18

Interaction of the DNA topoisomerase II catalytic inhibitor meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane (ICRF-193), a bisdioxopiperazine derivative, with the conserved region(s) of eukaryotic but not prokaryotic enzyme

Makoto Sato, Ryoji Ishida, Toshiharu Narita, +4

Biochemical Pharmacology

Cellular EnzymologyBiochemistryNatural SciencesConserved RegionMolecular Biology +4