Concepedia

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells

Tomáš Smutný, Michal Bitman, Michal Urban, Michaela Dubecka, Radim Vrzal, Zdeněk Dvořák, Petr Pávek

Archives of Toxicology · 2014 · 29 citations · 38 references

DOI

Concepts

References

38

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Margaret Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos et al. · Journal of Biological Chemistry · 1998 · 3K citations · Full text

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

Bryan Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell · 2000 · 1.9K citations · Full text

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

, , +18

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 917 citations · Full text

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