Synthesis, bioassay studies, and molecular docking of novel 5-substituted 1H tetrazoles as cyclooxygenase-2 (COX-2) inhibitors

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction

Jacqueline E. Milne, Stephen L. Buchwald · Journal of the American Chemical Society · 2004 · 431 citations

Natural Sciences, Chemical Engineering, Chemistry +17

Structural Analysis of NSAID Binding by Prostaglandin H₂ Synthase:  Time-Dependent and Time-Independent Inhibitors Elicit Identical Enzyme Conformations

Barry S. Selinsky, Kushol Gupta, Caroline T. Sharkey et al. · Biochemistry · 2001 · 289 citations

Medicine, Medicinal Chemistry, Pharmacology +15