Strategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational Methods

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ADVERTISEMENT RETURN TO ISSUEPREVAccountsNEXTStrategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational MethodsRichard A. Houghten*†, Clemencia Pinilla†, Marc A. Giulianotti†, Jon R. Appel†, Colette T. Dooley†, Adel Nefzi†, John M. Ostresh†, Yongping Yu⊥†, Gerald M. Maggiora‡, Jose L. Medina-Franco‡, Daniela Brunner§, and Jeff Schneider§∥View Author Information Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, BIO5 Institute and College of Pharmacy, University of Arizona, Tucson, Arizona 85721, PsychoGenics, Inc., 765 Old Saw Mill River Road, Tarrytown, New York 10591, and School of Computer Science, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213* To whom correspondence should be addressed. Phone: [phone] . Fax: [phone]. E-mail: [email protected]†Torrey Pines Institute for Molecular Studies.‡University of Arizona.§PsychoGenics, Inc.∥Carnegie Mellon University.⊥Current address: College of Pharmaceutical Science, Zijin Campus, Zhejiang University, Hangzhou 310058, P. R. China.Cite this: J. Comb. Chem. 2008, 10, 1, 3–19Publication Date (Web):December 8, 2007Publication History Received19 July 2007Published online8 December 2007Published inissue 1 January 2008https://pubs.acs.org/doi/10.1021/cc7001205https://doi.org/10.1021/cc7001205review-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views1161Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Assays,Drug discovery,Mixtures,Peptides and proteins,Scaffolds Get e-Alerts