John M. Ostresh

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

Aaron D. Schimmer, Kate Welsh, Clemencia Pinilla et al. · Cancer Cell · 2004 · 406 citations

Medicine, Apoptosis, Immunology +8

"Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity.

John M. Ostresh, Gregory M. Husar, Sylvie E. Blondelle et al. · Proceedings of the National Academy of Sciences · 1994 · 210 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +18

Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings

John M. Ostresh, James H. Winkle, Vince T. Hamashin et al. · Biopolymers · 1994 · 170 citations

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

Bing Z. Carter, Marcela Gronda, Zhiliang Wang et al. · Blood · 2005 · 125 citations · Full text

Solid-Phase Synthesis of Trisubstituted Bicyclic Guanidines via Cyclization of Reduced N-Acylated Dipeptides

John M. Ostresh, Christa C. Schoner, Vince T. Hamashin et al. · The Journal of Organic Chemistry · 1998 · 123 citations

Reduced N-acylated Dipeptides, Combinatorial Chemistry, Solid-phase Synthesis +10