Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Michael C. Alley, Dominic A. Scudiero, Anne Monks et al. · PubMed · 1988 · 3.1K citations

Chemoprevention Strategy, Tumor Biology, Microculture Tetrazolium Assay +16

X-linked IAP is a direct inhibitor of cell-death proteases

Quinn L. Deveraux, Ryōsuke Takahashi, Guy S. Salvesen et al. · Nature · 1997 · 1.9K citations

Protein Function, Apoptosis, Autophagy +5

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

Quinn L. Deveraux · The EMBO Journal · 1998 · 1.4K citations · Full text

Signal Transduction, Apoptosis, Immunology +9

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

Natalie Roy · The EMBO Journal · 1997 · 1.3K citations · Full text

Protein Function, Signal Transduction, Specific Caspases +12

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

Yasuyuki Suzuki, Yuzuru Imai, Hiroshi Nakayama et al. · Molecular Cell · 2001 · 1.1K citations · Full text

Mitophagy, Inducing Cell Death, Mitochondrial Function +11