Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Transcriptional Regulation, Protein Function, Signal Transduction +14

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

Vincent Chau, John W. Tobias, Andreas Bachmair et al. · Science · 1989 · 1.5K citations

Protein Assembly, Glycobiology, Molecular Biology +21

A 26 S protease subunit that binds ubiquitin conjugates.

Quinn L. Deveraux, Vicença Ustrell, Cecile M. Pickart et al. · Journal of Biological Chemistry · 1994 · 758 citations · Full text

Protein Chemistry, Protein Function, Protein Assembly +10

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

Avram Hershko, Aaron Ciechanover, H Heller et al. · Proceedings of the National Academy of Sciences · 1980 · 738 citations · Full text

Multiple Chains, Protein Assembly, Proteasome +18

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

C P, Clive A. Slaughter, George Demartino · Journal of Biological Chemistry · 1992 · 440 citations · Full text