A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

Michael A. Marletta, Poksyn S. Yoon, Radha Iyengar et al. · Biochemistry · 1988 · 1.6K citations

Life Sciences, Immunology, Microbiology +13

A novel selective broad-spectrum anti-DNA virus agent

Erik De Clercq, Ivan Rosenberg, Takashi Sakuma et al. · Nature · 1986 · 764 citations

Pharmacy, Medicinal Chemistry, Microbiology +9

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

Erik De Clercq, Takashi Sakuma, Masanori Baba et al. · Antiviral Research · 1987 · 513 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Prodrugs of Phosphates and Phosphonates

Scott J. Hecker, Mark D. Erion · Journal of Medicinal Chemistry · 2008 · 412 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

William A. Lee, Gong-Xin He, Eugene Eisenberg et al. · Antimicrobial Agents and Chemotherapy · 2005 · 339 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17