George Stepan

Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link, Martin S. Rhee, Winston C. Tse et al. · Nature · 2020 · 392 citations · Full text

Natural Sciences, Human Retrovirus, Immunology +10

Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

Kim W. McIntyre, George Stepan, Kenneth Kolinsky et al. · The Journal of Experimental Medicine · 1991 · 289 citations · Full text

Immunology, Immune Regulation, Immunologic Mechanism +20

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Datsen G. Wei, Vicki Chiang, Elizabeth Fyne et al. · PLoS Pathogens · 2014 · 278 citations · Full text

Immunodeficiencies, Immunology, Antiviral Drug +22

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

Manuel Tsiang, G.S. Jones, Joshua Goldsmith et al. · Antimicrobial Agents and Chemotherapy · 2016 · 274 citations · Full text

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant, Andrew Mulato, Derek Hansen et al. · Nature Medicine · 2019 · 157 citations · Full text

Medicine, Human Retrovirus, Immunology +8