Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link, Martin S. Rhee, Winston C. Tse, +70

Nature

Natural SciencesHuman RetrovirusImmunologyAntiviral TherapyMolecular Biology +8

Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

Kim W. McIntyre, George Stepan, Kenneth Kolinsky, +6

The Journal of Experimental Medicine

ImmunologyImmune RegulationImmunologic MechanismImmune SystemImmunotherapy +18

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Datsen G. Wei, Vicki Chiang, Elizabeth Fyne, +19

PLoS Pathogens

ImmunodeficienciesImmunologyAntiviral DrugImmunotherapyPersistent Latent Reservoir +20

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

Manuel Tsiang, G.S. Jones, Joshua Goldsmith, +15

Antimicrobial Agents and Chemotherapy

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant, Andrew Mulato, Derek Hansen, +27

Nature Medicine

MedicineHuman RetrovirusImmunologyAntiviral ResponseAntiviral Drug Development +6

<i>In Vitro</i> Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate

Christian Callebaut, George Stepan, Tian Yang, +1

Antimicrobial Agents and Chemotherapy

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

Joy Y. Feng, Yili Xu, Ona Barauskas, +11

Antimicrobial Agents and Chemotherapy

Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle

Richard L. Mackman, Victoria A. Steadman, David K. Dean, +36

Journal of Medicinal Chemistry

Human cloned α1A-adrenoceptor isoforms display α1L-adrenoceptor pharmacology in functional studies

Donald V. Daniels, Joel R. Gever, Jeffrey R. Jasper, +8

European Journal of Pharmacology

Molecular PharmacologyAdrenal GlandMedicinePhysiologyAdrenal Disease +3

Effect of aminophylline on cisplatin nephrotoxicity in the rat

H. Heidemann, St. Müller, L. Mertins, +3

British Journal of Pharmacology