Concepedia

Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P‐glycoprotein

Ling Ye, Tao Wang, Lan Tang, Wei Liu, Zhen Yang, Juan Zhou, Zhijie Zheng, Zheng Cai, Ming Hu, Zhongqiu Liu

Journal of Pharmaceutical Sciences · 2011 · 151 citations · 27 references

DOI

Concepts

References

27

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

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Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human

Alexander Panossian, Areg Hovhannisyan, G. Mamikonyan et al. · Phytomedicine · 2000 · 218 citations

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Andrographolide interferes with binding of nuclear factor‐<i>κ</i>B to DNA in HL‐60‐derived neutrophilic cells

María A. Hidalgo, Alex Romero, Jaime Figueroa et al. · British Journal of Pharmacology · 2005 · 160 citations · Full text

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Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model

Ming Hu, June Chen, Huimin Lin · Journal of Pharmacology and Experimental Therapeutics · 2003 · 139 citations

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Mechanisms Responsible for Poor Oral Bioavailability of Paeoniflorin: Role of Intestinal Disposition and Interactions with Sinomenine

Zhong Qiu Liu, Zhi‐Hong Jiang, Liang Liu et al. · Pharmaceutical Research · 2006 · 116 citations

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