Concepedia

AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib

Monica R. Maiello, Amelia D’Alessio, Antonella De Luca, Adele Carotenuto, Anna Maria Rachiglio, Maria Napolitano, Letizia Cito, Antonella Guzzo, Nicola Normanno

Breast Cancer Research and Treatment · 2006 · 17 citations · 21 references

DOI

Concepts

References

21

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

, , +16

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

David B. Whyte, Paul T. Kirschmeier, Tish Hockenberry et al. · Journal of Biological Chemistry · 1997 · 881 citations · Full text

, , +16

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

Kiyoko Kato, Adrienne D. Cox, Mark M. Hisaka et al. · Proceedings of the National Academy of Sciences · 1992 · 541 citations

, , +14

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.

Mark M. Moasser, Andrea Basso, Steven D. Averbuch et al. · PubMed · 2001 · 508 citations

, , +17

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

Roberto Bianco, Incheol Shin, Christoph A. Ritter et al. · Oncogene · 2003 · 453 citations

, , +16