Mark M. Hisaka

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

Kiyoko Kato, Adrienne D. Cox, Mark M. Hisaka et al. · Proceedings of the National Academy of Sciences · 1992 · 541 citations

Protein Secretion, Isoprenoid Addition, Amino Acid Substitutions +20

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

Adrienne D. Cox, Mark M. Hisaka, Janice E. Buss et al. · Molecular and Cellular Biology · 1992 · 180 citations

Genetics, Signal Recognition, Molecular Biology +17

Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.

L A Quilliam, Kiyoko Kato, K M Rabun et al. · Molecular and Cellular Biology · 1994 · 90 citations · Full text

Molecular Biology, Ras-gef Interaction, Cell Growth +16

Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.

Geoffrey Clark, Lawrence A. Quilliam, Mark M. Hisaka et al. · Proceedings of the National Academy of Sciences · 1993 · 57 citations · Full text

Molecular Regulation, Cytoskeleton, Cellular Physiology +18

Involvement of the Switch 2 Domain of Ras in Its Interaction with Guanine Nucleotide Exchange Factors

Lawrence A. Quilliam, Mark M. Hisaka, Sheng Zhong et al. · Journal of Biological Chemistry · 1996 · 52 citations · Full text