Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Genes Expressed in Human Tumor Endothelium

Brad St. Croix, Carlo Rago, Victor E. Velculescu et al. · Science · 2000 · 1.8K citations

Medicine, Molecular Biology, Oncology +12

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

Timothy M. Browder, Catherine Butterfield, Birgit M. Kräling et al. · PubMed · 2000 · 1.6K citations

Medicine, Oncology, Pharmacology +16

Angiostatin induces and sustains dormancy of human primary tumors in mice

Michael S. O’Reilly, Lars Holmgren, Catherine Chen et al. · Nature Medicine · 1996 · 1.2K citations

Medicine, Oncology, Pharmacology +16

Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.

Guido Bocci, K. C. Nicolaou, Robert S. Kerbel · PubMed · 2002 · 445 citations

Medicine, Oncology, Pharmacology +16