Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

The genetic determinants of the CYP3A5 polymorphism

Elisabeth Hustert, Michael Haberl, Oliver Burk et al. · Pharmacogenetics · 2001 · 670 citations

Medicine, Genetics, Molecular Genetics +13

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

Medicine, Genetics, Molecular Genetics +17

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

Thomas K. H. Chang, Georg F. Weber, Charles L. Crespi et al. · PubMed · 1993 · 550 citations

Medicine, Pharmacology, Biochemical Pharmacology +16

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17