Ivar Roots

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>

Sven Hoffmeyer, Oliver Burk, Oliver von Richter et al. · Proceedings of the National Academy of Sciences · 2000 · 2.4K citations

Medicine, Molecular Genetics, Pharmacology +15

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · PubMed · 1997 · 979 citations

Medicine, Genetics, Pharmacology +17

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · British Journal of Clinical Pharmacology · 1999 · 750 citations · Full text

Life Sciences, Genetics, Pharmacology +14

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

Julia Kirchheiner, Harald Schmidt, Mladen V. Tzvetkov et al. · The Pharmacogenomics Journal · 2006 · 439 citations

Medicine, Pharmacokinetics, Pharmacology +15

CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants:
a first step towards subpopulation‐specific dosages

Julia Kirchheiner, Kim Brøsen, Marja­‐Liisa Dahl et al. · Acta Psychiatrica Scandinavica · 2001 · 423 citations

Medicine, Pharmacokinetics, Pharmacology +17