Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Meishiang Jang, Lining Cai, George Udeani et al. · Science · 1997 · 4.9K citations

Medicine, Oncology, Pharmacology +17

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

Life Sciences, Cell Biology, Molecular Biology +14

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani et al. · Cancer Cell · 2012 · 1.4K citations · Full text

Life Sciences, Biochemistry, Molecular Medicine +16