BIOTRANSFORMATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN PERIPHERAL HUMAN LUNG MICROSOMES

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

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Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

Yune‐Fang Ueng, Takashi Kuwabara, Young‐Jin Chun et al. · Biochemistry · 1997 · 386 citations

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Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

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Medicine, Molecular Biology, Molecular Genetics +9

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ta‐Chen Su, Ziping Bao, Qingyu Zhang et al. · PubMed · 2000 · 342 citations

Medicine, Pharmacology, Toxicology +10

Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.

William L. Smith, D L DeWitt · PubMed · 1995 · 285 citations

Life Sciences, Biochemistry, Pharmacology +15