Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.

James W. Prichard, Douglas L. Rothman, Edward J. Novotny, +6

Proceedings of the National Academy of Sciences

Lactate RiseNeurophysiological BiomarkersPhysiologic StimulationSocial SciencesNeurology +18

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

Yune‐Fang Ueng, Takashi Kuwabara, Young‐Jin Chun, +1

Biochemistry

Aldo-keto ReductaseMolecular BiologyChemistryRedox BiologyToxicological Mechanism +14

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

Edward A. Sausville, Susan G. Arbuck, Richard A. Messmann, +12

Journal of Clinical Oncology

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

Eiichi Fuse, Hiromi Tanii, Noriaki Kurata, +14

PubMed

Molecular PharmacologyAlpha1-acid GlycoproteinUnusual PharmacokineticsOncologyGlycosylation +12

Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models

Edward A. Sausville, Richard D. Lush, Donna Headlee, +8

Cancer Chemotherapy and Pharmacology

Molecular PharmacologyPharmacological StudyPreclinical ModelsMedicineClinical Pharmacology +4

CYP3A4 Is Mainly Responsibile for the Metabolism of a New Vinca Alkaloid, Vinorelbine, in Human Liver Microsomes

Jiro Kajita, Takashi Kuwabara, Hiroyuki Kobayashi, +1

Drug Metabolism and Disposition

Elevation of cerebral lactate detected by localized sup 1 H-magnetic resonance spectroscopy in migraine during the interictal period

Hiroshi Watanabe, Takashi Kuwabara, M Ohkubo, +2

Neurology

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans.

Eiichi Fuse, Hiromi Tanii, K Takai, +6

PubMed

Alpha1-acid GlycoproteinAltered PharmacokineticsBiochemistryHuman AgpMedicine +12

Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans.

Takashi Kuwabara, Yoshinori Katō, Satoshi Kobayashi, +2

Journal of Pharmacology and Experimental Therapeutics

LC–MS/MS coupled with immunoaffinity extraction for determination of estrone, 17β-estradiol and estrone 3-sulfate in human plasma

Jun Hosogi, Hideyuki Tanaka, Kazuhiro Fujita, +5

Journal of Chromatography B

MedicineBioanalysisMass SpectrometryImmunoaffinity ExtractionGynecology +8