Concepedia

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Xiuju Dai, Koji Sayama, Mikiko Tohyama, Yuji Shirakata, Yasushi Hanakawa, Sho Tokumaru, Lüjun Yang, Satoshi Hirakawa, Koji Hashimoto

Journal of Allergy and Clinical Immunology · 2011 · 171 citations · 46 references

DOI

Concepts

References

46

The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp · Molecular Cell · 2002 · 6K citations · Full text

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton et al. · Nature · 2006 · 3K citations

, , +7

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Veit Hornung, Franz Bauernfeind, Annett Halle et al. · Nature Immunology · 2008 · 3K citations · Full text

, , +13

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

, , +16

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle, Veit Hornung, Gabor C. Petzold et al. · Nature Immunology · 2008 · 2.4K citations · Full text

, , +13