Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · British Journal of Clinical Pharmacology · 1999 · 750 citations · Full text

Life Sciences, Genetics, Pharmacology +14

Anti-inflammatory effects of low-dose oral theophylline in atopic asthma

Patrick S. Sullivan, ZH Jaffar, Clive Page et al. · The Lancet · 1994 · 406 citations

Medicine, Immunology, Pharmacology +13

Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans

Mitsutoshi Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · The Journal of Biochemistry · 1999 · 347 citations

Medicine, Molecular Genetics, Pharmacology +12

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

Lie Gu, Frank J. Gonzalez, W. Kalow et al. · Pharmacogenetics · 1992 · 326 citations

Medicine, Biochemistry, Pharmacology +17