Concepedia

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Patrick R. Verhoest, Caroline Proulx-LaFrance, Michael L. Corman, Lois K. Chenard, Christopher J. Helal, Xinjun Hou, Robin J. Kleiman, Shenping Liu, Eric S. Marr, Frank S. Menniti,

Journal of Medicinal Chemistry · 2009 · 65 citations · 17 references

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Abstract

By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.

References

17

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

, , +15

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

, , +14

Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming

Daniel K. Gehlhaar, Gennady M. Verkhivker, Paul A. Rejto et al. · Chemistry & Biology · 1995 · 685 citations · Full text

, , +17

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 431 citations · Full text

, , +14

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

Don K. Walker · Xenobiotica · 1999 · 401 citations

, , +16