Lois K. Chenard

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Patrick R. Verhoest, Caroline Proulx-LaFrance, Michael L. Corman et al. · Journal of Medicinal Chemistry · 2009 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

3‘-Aminoadenosine-5‘-uronamides:  Discovery of the First Highly Selective Agonist at the Human Adenosine A ₃ Receptor

Michael P. DeNinno, Hiroko Masamune, Lois K. Chenard et al. · Journal of Medicinal Chemistry · 2002 · 59 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

Christopher J. Helal, Zhijun Kang, Xinjun Hou et al. · Journal of Medicinal Chemistry · 2011 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 <i>H</i> -pyrazolo-[3,4- <i>b</i> ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

Lei Zhang, Gayatri Balan, Gabriela Barreiro et al. · Journal of Medicinal Chemistry · 2014 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Design and optimization of selective azaindole amide M1 positive allosteric modulators

Jennifer E. Davoren, Steven V. O’Neil, Dennis P. Anderson et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +13