Concepedia

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors

Gary Tresadern, Francisca Delgado, Óscar Delgado, Harrie J. M. Gijsen, Gregor J. Macdonald, Dieder Moechars, Frederik Rombouts, Richard Alexander, John Spurlino, Michiel Van Gool,

Bioorganic & Medicinal Chemistry Letters · 2011 · 44 citations · 26 references

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26

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

, , +17

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8

Treatment of Alzheimer's disease; current status and new perspectives

Elio Scarpini, Philip Schelterns, Howard Feldman · The Lancet Neurology · 2003 · 725 citations

, , +14

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 706 citations

, , +17