Concepedia

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

Jun Chen, Sandhya Xavier, Eliza Moskowitz-Kassai, Robert Chen, Connie Y. Lu, Kyle Sanduski, Aleš Špes, Boris Turk, Michael S. Goligorsky

American Journal Of Pathology · 2012 · 115 citations · 28 references

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

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Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 7K citations · Full text

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

In Hye Lee, Liu Cao, Raúl Mostoslavsky et al. · Proceedings of the National Academy of Sciences · 2008 · 1.4K citations · Full text

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