Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production

Analysis of optimality in natural and perturbed metabolic networks

Daniel Segrè, Dennis Vitkup, George M. Church · Proceedings of the National Academy of Sciences · 2002 · 1.4K citations

Life Sciences, Biochemistry, Biology +15

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

Judith Becker, Oskar Zelder, Stefan S. Hafner et al. · Metabolic Engineering · 2011 · 609 citations

Life Sciences, Bioengineering, Biotechnology +16

Evolutionary programming as a platform for in silico metabolic engineering

Kiran Raosaheb Patil, Isabel Rocha, Jochen Förster et al. · BMC Bioinformatics · 2005 · 466 citations · Full text

Life Sciences, Bioengineering, Biotechnology +16

An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems

Priti Pharkya, Costas D. Maranas · Metabolic Engineering · 2005 · 334 citations

Life Sciences, Chemical Engineering, Microbiology +17

Minimal <i>Escherichia coli</i> Cell for the Most Efficient Production of Ethanol from Hexoses and Pentoses

Cong T. Trinh, Pornkamol Unrean, Friedrich Srienc · Applied and Environmental Microbiology · 2008 · 284 citations

Life Sciences, Biochemistry, Microbiology +17