The intracellular phosphorylation of (−)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair et al. · Proceedings of the National Academy of Sciences · 1986 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +8

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

Raymond F. Schinazi, Robert M. Lloyd, M. Hong Nguyen et al. · Antimicrobial Agents and Chemotherapy · 1993 · 367 citations

Life Sciences, Infectious Diseases, Pharmacology +14

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

Charles A. Boucher, N. Cammack, P Schipper et al. · Antimicrobial Agents and Chemotherapy · 1993 · 319 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13