Charles R. Penn

Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 240 citations · Full text

Medicine, Infectious Diseases, Pharmacology +10

Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en

Larisa V. Gubareva, Richard C. Bethell, Graham Hart et al. · Journal of Virology · 1996 · 204 citations · Full text

Life Sciences, Biology, Infectious Diseases +17

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

Graham Hart, David Orr, Charles R. Penn et al. · Antimicrobial Agents and Chemotherapy · 1992 · 170 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +15