N. Cammack

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

Charles A. Boucher, N. Cammack, P Schipper et al. · Antimicrobial Agents and Chemotherapy · 1993 · 319 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

Fueling Open‐Source Drug Discovery: 177 Small‐Molecule Leads against Tuberculosis

Lluís Ballell, Robert H. Bates, Rob J. Young et al. · ChemMedChem · 2013 · 310 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 240 citations · Full text

Medicine, Infectious Diseases, Pharmacology +10

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

Qing Gao, Zhenyong Gu, Michael A. Parniak et al. · Antimicrobial Agents and Chemotherapy · 1993 · 230 citations · Full text

Life Sciences, Microbiology, Molecular Genetics +17