Michael A. Parniak

Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT):  Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

Dominique Arion, Neerja Kaushik, Suzanne McCormick et al. · Biochemistry · 1998 · 339 citations

Life Sciences, Biology, Molecular Biology +17

Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase

Mark A. Wainberg, William C. Drosopoulos, Horacio Salomón et al. · Science · 1996 · 304 citations

Life Sciences, Pharmacology, Pharmacotherapy +17

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

Qing Gao, Zhenyong Gu, Michael A. Parniak et al. · Antimicrobial Agents and Chemotherapy · 1993 · 230 citations · Full text

Life Sciences, Microbiology, Molecular Genetics +17

Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine

Z Gu, Qing Gao, X Li et al. · Journal of Virology · 1992 · 229 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

Zhengxian Gu, Qing Gao, Hengsheng Fang et al. · Antimicrobial Agents and Chemotherapy · 1994 · 213 citations · Full text

Life Sciences, Genetics, Molecular Genetics +14