Concepedia

Beta Defensin-2 Is Reduced in Central but Not in Distal Airways of Smoker COPD Patients

Elisabetta Pace, Maria Ferraro, Marta I. Minervini, Patrizio Vitulo, Loredana Pipitone, Giuseppina Chiappara, Liboria Siena, Angela Marina Montalbano, Malcolm Johnson, Mark Gjomarkaj

PLoS ONE · 2012 · 79 citations · 33 references

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Abstract

This study provides new insights on the possible mechanisms involved in the alteration of innate immunity mechanisms in COPD.

References

33

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

Christopher J L Murray, Alan D López · The Lancet · 1997 · 7K citations

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Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

Arya Biragyn, Pier Adelchi Ruffini, Cynthia A. Leifer et al. · Science · 2002 · 885 citations

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CD8 <sup>+</sup> T-Lymphocytes in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease

Marina Saetta, Antonino Di Stefano, Graziella Turato et al. · American Journal of Respiratory and Critical Care Medicine · 1998 · 787 citations

The Economic Burden of COPD

Sean D. Sullivan, Scott D. Ramsey, Todd A. Lee · CHEST Journal · 2000 · 577 citations

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A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the Colon

Klaus Fellermann, Daniel E. Stange, Elke Schaeffeler et al. · The American Journal of Human Genetics · 2006 · 559 citations · Full text

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