Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™)

A Structural Basis for the Chiral Preferences of Lipases

Mirosław Cygler, Paweł Grochulski, Romas J. Kazlauskas et al. · Journal of the American Chemical Society · 1994 · 300 citations

Life Sciences, Biochemistry, Chemistry +13

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Jonathon Alexis Coates, N. Cammack, H J Jenkinson et al. · Antimicrobial Agents and Chemotherapy · 1992 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

Raymond F. Schinazi, C. K. CHU, A Peck et al. · Antimicrobial Agents and Chemotherapy · 1992 · 265 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Organoalkali compounds by radical anion induced reductive metalation of phenyl thioethers

Theodore Cohen, M. Bhupathy · Accounts of Chemical Research · 1989 · 258 citations

Natural Sciences, Chemistry, Inorganic Chemistry +5

Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

Joseph Warren Beach, Lak Shin Jeong, Antônio J. Alves et al. · The Journal of Organic Chemistry · 1992 · 192 citations

Medicine, Medicinal Chemistry, Pharmacology +6