Joseph Warren Beach

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

Raymond F. Schinazi, C. K. CHU, A Peck et al. · Antimicrobial Agents and Chemotherapy · 1992 · 265 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

C.N. Chang, Shin-Lian Doong, Junhu Zhou et al. · Journal of Biological Chemistry · 1992 · 225 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +13

Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

Joseph Warren Beach, Lak Shin Jeong, Antônio J. Alves et al. · The Journal of Organic Chemistry · 1992 · 192 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Asymmetric synthesis and biological evaluation of .beta.-L-(2R,5S)- and .alpha.-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents

Lak Shin Jeong, Raymond F. Schinazi, Joseph Warren Beach et al. · Journal of Medicinal Chemistry · 1993 · 130 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

Hea O. Kim, Soon Kil Ahn, Antônio J. Alves et al. · Journal of Medicinal Chemistry · 1992 · 121 citations

Pharmacy, Chemistry, Medicinal Chemistry +13