Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase

Jingshan Ren, John Milton, Kurt Weaver, +3

Structure

Viral ReplicationDrug Resistance MutationsNatural SciencesGeneticsHuman Retrovirus +10

Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer Agents

Swarna A. Gamage, Julie A. Spicer, Gordon W. Rewcastle, +7

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +14

Novel Angular Benzophenazines:  Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents

Nigel Vicker, Luke Burgess, Irina Chuckowree, +15

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryChemoprevention StrategyMedicine +13

Phenylethylthiazolylthiourea (PETT) Non-nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases

Jingshan Ren, Jonathan M. Diprose, Jonathan Warren, +8

Journal of Biological Chemistry

Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1.

Andrew L. Hopkins, Jingshan Ren, John Milton, +4

Journal of Medicinal Chemistry

Molecular BiologyAntiviral DrugQuinolone NnrtisChemical BiologyDrug Resistance +17

Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance

Shouming Wang, Adrian Folkes, Irina Chuckowree, +14

Journal of Medicinal Chemistry

Drug TargetMultidrug ResistanceSelective InhibitorsPharmacotherapyAntimicrobial Chemotherapy +15

Structure–activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576

Shouming Wang, Warren Miller, John Milton, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryNatural SciencesMedicine +10

Design of Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 2.

George A. Freeman, C. Webster Andrews, Andrew L. Hopkins, +18

Journal of Medicinal Chemistry

Molecular BiologyPharmacotherapyAntiviral DrugDrug ResistanceMedicinal Chemistry +16

New Cyclodextrin‐Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Molecules

Valentina Oliveri, Antonino Puglisi, Maurizio Viale, +6

Chemistry - A European Journal

Multifunctional MoleculesBiochemistryCyclodextrin MoietyMedicineCyclodextrin Production +5

Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™)

John Milton, Stephen Brand, Martin F. Jones, +1

Tetrahedron Letters

Medicinal ChemistryMedicineAntiviral Drug DevelopmentVirologyEnantioselective Enzymatic Synthesis +3