Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 393 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1999 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors

David R. Helton, J P Tizzano, James A. Monn et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 282 citations

Medicine, Neuroscience, Pharmacology +15

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

Frédéric Knoflach, Vincent Mutel, Synèse Jolidon et al. · Proceedings of the National Academy of Sciences · 2001 · 236 citations · Full text

Medicine, Neuroscience, Pharmacology +17

SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5

Mark A. Varney, Nicholas D. P. Cosford, Christine Jachec et al. · Journal of Pharmacology and Experimental Therapeutics · 1999 · 189 citations

Medicine, Neuroscience, Pharmacology +17