Concepedia

Allosteric Potentiation

Allosteric Potentiation is a type of allosteric modulation wherein a ligand binds to an allosteric site on a receptor to enhance the receptor's functional response to its primary agonist without directly activating the receptor itself.

70

Publications

5.2K

Citations

427

Authors

121

Institutions

Publications per year

2017–2026

10

Parents

Publications

70

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

Isao Ito, Shuichi Tanabe, A Kohda et al. · The Journal of Physiology · 1990 · 323 citations · Full text

, , +17

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney, Julie A. O’Brien, Wei Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 299 citations

, , +17

Selective activation of the M <sub>1</sub> muscarinic acetylcholine receptor achieved by allosteric potentiation

Lei Ma, Matthew A. Seager, Marion Wittmann et al. · Proceedings of the National Academy of Sciences · 2009 · 284 citations · Full text

, , +17

Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

Gareth T. Young, Ruud Zwart, Alison Walker et al. · Proceedings of the National Academy of Sciences · 2008 · 263 citations · Full text

, , +17

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Guido Veit, Ariel Roldán, Mark A. Hancock et al. · JCI Insight · 2020 · 261 citations · Full text

, , +15

1–5 of 70

Authors

427

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    7 publications · 1.1K citations

    7

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    4 publications · 958 citations

    4

    h-index

  3. MA
    Marlene A. Jacobson

    United States Military Academy, United States

    3 publications · 755 citations

    3

    h-index

  4. BA
    Blake A. Rowe

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    3 publications · 247 citations

    3

    h-index

  5. HS
    Hervé Schaffhauser

    General Atomics (United States), United States

    3 publications · 247 citations

    3

    h-index

1–5 of 427

Institutions

121

  1. Vanderbilt University Medical Center

    Nashville, United States

    5 h-index

    6 publications

    626 citations

  2. United States Military Academy

    West Point, United States

    3 h-index

    3 publications

    755 citations

  3. University of Florida

    Gainesville, United States

    3 h-index

    18 publications

    297 citations

  4. Northeastern University

    Boston, United States

    3 h-index

    21 publications

    388 citations

  5. Vanderbilt University

    Nashville, United States

    3 h-index

    5 publications

    442 citations

  6. Eli Lilly (United States)

    Indianapolis, United States

    3 h-index

    46 publications

    2.1K citations

  7. Servier (France)

    Neuilly-sur-Seine, France

    3 h-index

    13 publications

    397 citations

  8. United Arab Emirates University

    Al Ain, United Arab Emirates

    2 h-index

    11 publications

    346 citations

1–8 of 121

Venues

  1. 11

    h-index

  2. Molecular Pharmacology

    10 publications · 632 citations

    10

    h-index

  3. Neuropharmacology

    5 publications · 199 citations

    5

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    4 publications · 140 citations

    4

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 635 citations

    3

    h-index

1–5