Ariel Roldán

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Tsukasa Okiyoneda, Guido Veit, Johanna F. Dekkers et al. · Nature Chemical Biology · 2013 · 390 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +10

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

Wael M. Rabeh, Florian Bossard, Haijin Xu et al. · Cell · 2012 · 291 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Guido Veit, Ariel Roldán, Mark A. Hancock et al. · JCI Insight · 2020 · 261 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Guido Veit, Haijin Xu, Elise Dréano et al. · Nature Medicine · 2018 · 139 citations

Pharmacy, Medicinal Chemistry, Pharmacotherapy +11

Characterization of a Putative α-Helix across the Capsid-SP1 Boundary That Is Critical for the Multimerization of Human Immunodeficiency Virus Type 1 Gag

Chen Liang, Jing Hu, Rodney S. Russell et al. · Journal of Virology · 2002 · 102 citations · Full text

Life Sciences, Biology, Molecular Biology +17