David R. Helton

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 392 citations

Pharmacological Characterization, Active Group 2, Psychotropic Medication +16

Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors

David R. Helton, J P Tizzano, James A. Monn et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 282 citations

LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

David R. Helton, Joseph P. Tizzano, James A. Monn et al. · Neuropharmacology · 1997 · 103 citations

Molecular Pharmacology, Nicotine Withdrawal, Behavioral Neuroscience +10

2-Substituted (2<i>SR</i>)-2-Amino-2-((1<i>SR</i>,2<i>SR</i>)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Paul L. Ornstein, Thomas J. Bleisch, M. Brian Arnold et al. · Journal of Medicinal Chemistry · 1998 · 100 citations · Full text

Pharmacological Characterization, Synaptic Transmission, Pharmacotherapy +19

Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity

David R. Helton, Deah Modlin, Joseph P. Tizzano et al. · Psychopharmacology · 1993 · 82 citations

Tobacco Control, Substance Abuse, Behavioral Sciences +15