Joseph P. Tizzano

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 393 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1999 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

Xia Li, Joseph P. Tizzano, Kelly Griffey et al. · Neuropharmacology · 2001 · 224 citations

Medicine, Neuroscience, Pharmacology +12

Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of <i>N</i>-(4-(2-Methoxyphenoxy)phenyl)-<i>N</i>-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine

Michael P. Johnson, Melvyn Baez, G. Erik Jagdmann et al. · Journal of Medicinal Chemistry · 2003 · 182 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

Linda M. Rorick‐Kehn, Bryan G. Johnson, Karen M. Knitowski et al. · Psychopharmacology · 2007 · 157 citations

Medicine, Pharmacology, Psychiatry +8