Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9 * 3 allele

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

Guruprasad P. Aithal, Christopher P. Day, Patrick Kesteven et al. · The Lancet · 1999 · 1.2K citations

Medicine, Pharmacokinetics, Pharmacology +12

Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy

Hirokazu Furuya, Pedro M. Fernández‐Salguero, W. Larry Gregory et al. · Pharmacogenetics · 1995 · 280 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +14

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

T. Leemann, C. Transon, Pierre Dayer · Life Sciences · 1993 · 267 citations

Medicine, Pharmacokinetics, Pharmacology +17

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

Roque Bort, Katherine Macé, Alan R. Boobis et al. · Biochemical Pharmacology · 1999 · 236 citations

Medicine, Pharmacokinetics, Pharmacology +14

Genetic Polymorphism of Cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese Population

Miyuki Kimura, Ichiro Ieiri, Kohsuke Mamiya et al. · Therapeutic Drug Monitoring · 1998 · 207 citations

Life Sciences, Genetics, Pharmacology +15