Deep mutational scanning: a new style of protein science

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

Jacob A. Tennessen, Abigail W. Bigham, Timothy D. O’Connor et al. · Science · 2012 · 1.7K citations · Full text

Genetics, Genetic Epidemiology, Molecular Genetics +31

Protein structure prediction from sequence variation

Debora S. Marks, Thomas A. Hopf, Chris Sander · Nature Biotechnology · 2012 · 667 citations · Full text

Sequence Variation, Computational Biology, Molecular Biology +6

High-resolution mapping of protein sequence-function relationships

Douglas M. Fowler, Carlos L. Araya, Sarel J. Fleishman et al. · Nature Methods · 2010 · 597 citations · Full text

Functional Genomics, Natural Sciences, Medicine +9

Principles for designing ideal protein structures

Nobuyasu Koga, Rie Koga, Gaohua Liu et al. · Nature · 2012 · 583 citations · Full text

Ideal Protein Structures, Biomolecular Structure Prediction, Protein Folding +8

The spatial architecture of protein function and adaptation

Richard N. McLaughlin, Frank J. Poelwijk, Arjun S. Raman et al. · Nature · 2012 · 472 citations

Biology, Protein Function, Protein Folding +4