Concepedia

Mutagenesis Scanning

Mutagenesis Scanning is a systematic experimental method in protein interaction mapping that involves the targeted introduction of mutations across a protein sequence to identify specific residues critical for interaction, thereby revealing functional hotspots within protein interfaces.

51

Publications

4.3K

Citations

252

Authors

95

Institutions

Publications per year

2017–2026

11

Parents

Publications

51

Deep mutational scanning: a new style of protein science

Douglas M. Fowler, Stanley Fields · Nature Methods · 2014 · 1.5K citations · Full text

, , +11

A statistical framework for analyzing deep mutational scanning data

Alan F. Rubin, Hannah Gelman, Nathan Lucas et al. · Genome biology · 2017 · 313 citations · Full text

, , +14

Measuring the activity of protein variants on a large scale using deep mutational scanning

Douglas M. Fowler, Jason J. Stephany, Stanley Fields · Nature Protocols · 2014 · 225 citations · Full text

, , +14

Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.

Osamu Moro, Jelveh Lameh, Petra Högger et al. · Journal of Biological Chemistry · 1993 · 223 citations · Full text

, , +16

A binding motif for Siah ubiquitin ligase

Colin M. House, Ian J. Frew, Huei-Luen Huang et al. · Proceedings of the National Academy of Sciences · 2003 · 150 citations

, , +17

1–5 of 51

Authors

252

  1. DM
    Douglas M. Fowler

    University of Washington, United States

    3 publications · 2K citations

    3

    h-index

  2. SF
    Stanley Fields

    University of Washington, United States

    3 publications · 1.7K citations

    3

    h-index

  3. HR
    H. Ronald Kaback

    University of California, Los Angeles, United States

    2 publications · 52 citations

    2

    h-index

  4. PK
    Paul Kellam

    Wellcome Sanger Institute, United Kingdom

    1 publications · 17 citations

    1

    h-index

  5. AA
    Anthony A. Kossiakoff

    University of Chicago, United States

    1 publications · 35 citations

    1

    h-index

1–5 of 252

Institutions

95

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    14 publications

    531 citations

  2. University of California, San Francisco

    San Francisco, United States

    4 h-index

    17 publications

    1.2K citations

  3. University of Washington

    Seattle, United States

    4 h-index

    12 publications

    5.2K citations

  4. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    5 publications

    327 citations

  5. Peter MacCallum Cancer Centre

    Melbourne, Australia

    2 h-index

    10 publications

    1.8K citations

  6. Washington University in St. Louis

    St Louis, United States

    2 h-index

    7 publications

    174 citations

  7. Stockholm University

    Stockholm, Sweden

    2 h-index

    4 publications

    239 citations

  8. University of Washington Medical Center

    Seattle, United States

    2 h-index

    2 publications

    1.5K citations

1–8 of 95

Venues

  1. Journal of Biological Chemistry

    JBC · 12 publications · 706 citations

    12

    h-index

  2. Biochemistry

    4 publications · 96 citations

    4

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 367 citations

    4

    h-index

  4. Protein Science

    PS · 2 publications · 87 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 142 citations

    2

    h-index

1–5