Ian J. Frew

Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia

Koh Nakayama, Ian J. Frew, Mette K. Hagensen et al. · Cell · 2004 · 401 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Rouven Hoefflin, Sabine Harlander, Silvia Schäfer et al. · Nature Communications · 2020 · 284 citations · Full text

Medicine, Genetics, Oncology +17

pVHL and GSK3β are components of a primary cilium-maintenance signalling network

Claudio R. Thoma, Ian J. Frew, Christian R. Hoerner et al. · Nature Cell Biology · 2007 · 241 citations

Life Sciences, Cell Biology, Molecular Biology +10

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

Ian J. Frew, Claudio R. Thoma, Strahil Georgiev et al. · The EMBO Journal · 2008 · 159 citations · Full text

Medicine, Molecular Biology, Oncology +14

VHL loss causes spindle misorientation and chromosome instability

Claudio R. Thoma, Alberto Toso, Katrin L. Gutbrodt et al. · Nature Cell Biology · 2009 · 158 citations

Life Sciences, Cell Biology, Molecular Biology +16