Global Identification of Modular Cullin-RING Ligase Substrates

Michael J. Emanuele, Andrew E. H. Elia, Qikai Xu, +9

Cell

Protein AssemblyStructural BioinformaticsProtein FoldingGlobal IdentificationNatural Sciences +4

pVHL and GSK3β are components of a primary cilium-maintenance signalling network

Claudio R. Thoma, Ian J. Frew, Christian R. Hoerner, +3

Nature Cell Biology

Signal TransductionSignaling PathwayMolecular PathwayCell RegulationCellular Regulatory Mechanism +6

Analysis of microtubule dynamic instability using a plus-end growth marker

Alexandre Matov, Kathryn T. Applegate, Praveen Kumar, +4

Nature Methods

MechanobiologyMicrotubule Dynamic InstabilityDevelopmental BiologyCytoskeletonMedicine +1

VHL loss causes spindle misorientation and chromosome instability

Claudio R. Thoma, Alberto Toso, Katrin L. Gutbrodt, +7

Nature Cell Biology

ChromatinGenome InstabilityVhl LossGeneticsChromosome Biology +3

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

Ian J. Frew, Claudio R. Thoma, Strahil Georgiev, +5

The EMBO Journal

UrologyGenitourinary CancerKidney ResearchMedicinePathology +6

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia

Peter Schraml, Ian J. Frew, Claudio R. Thoma, +4

Modern Pathology

UrologyRenal CystsGenitourinary CancerClear CellSurgical Pathology +10

Priming-Dependent Phosphorylation and Regulation of the Tumor Suppressor pVHL by Glycogen Synthase Kinase 3

Alexander Hergovich, Joanna Lisztwan, Claudio R. Thoma, +3

Molecular and Cellular Biology

Tumor Suppressor PvhlCytoskeletonMt StabilizationCellular PhysiologyTumor Biology +14

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Martin Schröder, Martin Renatus, Xiaoyou Liang, +37

Nature Communications

Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability

Claudio R. Thoma, Alexandre Matov, Katrin L. Gutbrodt, +4

The Journal of Cell Biology

The VHL Tumor Suppressor: Riding Tandem with GSK3β in Primary Cilium Maintenance

Claudio R. Thoma, Ian J. Frew, Wilhelm Krek

Cell Cycle