Concepedia

Deep Mutational Scanning

Deep Mutational Scanning is a high-throughput experimental methodology that systematically assesses the functional impact of a comprehensive set of mutagenic variants in a biological system by coupling genotype with phenotypic selection through iterative sequencing and enrichment cycles.

234

Publications

18.5K

Citations

1.3K

Authors

396

Institutions

Publications per year

2017–2026

197

Variants

Dms

Parents

Publications

234

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Tyler N. Starr, Allison J. Greaney, Sarah K. Hilton et al. · Cell · 2020 · 2.2K citations · Full text

, , +16

Deep mutational scanning: a new style of protein science

Douglas M. Fowler, Stanley Fields · Nature Methods · 2014 · 1.5K citations · Full text

, , +11

Genome-wide prediction of disease variant effects with a deep protein language model

Nadav Brandes, Grant Goldman, Charlotte H. Wang et al. · Nature Genetics · 2023 · 441 citations · Full text

, , +16

CADD v1.7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions

Max Schubach, Lusiné Nazaretyan, Sebastian Röner et al. · Nucleic Acids Research · 2024 · 404 citations · Full text

, , +17

Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

Andrew D. Garst, Marcelo C. Bassalo, Gur Pines et al. · Nature Biotechnology · 2016 · 390 citations

, , +16

1–5 of 234

Authors

1.3K

  1. JD
    Jesse D. Bloom

    Fred Hutch Cancer Center, United States

    41 publications · 5.4K citations

    29

    h-index

  2. TN
    Tyler N. Starr

    Howard Hughes Medical Institute, United States

    15 publications · 3.5K citations

    13

    h-index

  3. BD
    Bernadeta Dadonaite

    Fred Hutch Cancer Center, United States

    11 publications · 943 citations

    11

    h-index

  4. DM
    Douglas M. Fowler

    University of Washington, United States

    10 publications · 2.6K citations

    10

    h-index

  5. DV
    David Veesler

    University of Washington, United States

    10 publications · 3.3K citations

    10

    h-index

1–5 of 1.3K

Institutions

396

  1. University of Washington

    Seattle, United States

    34 h-index

    215 publications

    46.2K citations

  2. Fred Hutch Cancer Center

    Seattle, United States

    30 h-index

    192 publications

    27.4K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    30 h-index

    81 publications

    9.5K citations

  4. University of California, San Francisco

    San Francisco, United States

    12 h-index

    190 publications

    10.8K citations

  5. University of Illinois Urbana-Champaign

    Urbana, United States

    10 h-index

    52 publications

    3.3K citations

  6. Scripps Research Institute

    San Diego, United States

    8 h-index

    19 publications

    1.6K citations

  7. Case Western Reserve University

    Cleveland, United States

    8 h-index

    12 publications

    694 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    17 publications

    781 citations

1–8 of 396

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 30 publications · 957 citations

    17

    h-index

  2. eLife

    18 publications · 1.4K citations

    16

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.3K citations

    14

    h-index

  4. Nature Communications

    10 publications · 551 citations

    9

    h-index

  5. PLoS Pathogens

    8 publications · 540 citations

    8

    h-index

1–5