Concepedia

Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors

Paweł Nowak, Derek C. Cole, Ann Aulabaugh, Jonathan Bard, Rajiv Chopra, Rebecca Cowling, Kristi Fan, Baihua Hu, Steve Jacobsen, Minakshi Jani,

Bioorganic & Medicinal Chemistry Letters · 2009 · 27 citations · 18 references

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Forecasting the global burden of Alzheimer's disease

Ron Brookmeyer, Elizabeth M. Johnson, Kathryn Ziegler‐Graham et al. · Alzheimer s & Dementia · 2007 · 3.4K citations

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High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

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BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

Michael Farzan, Christine E. Schnitzler, Natalya Vasilieva et al. · Proceedings of the National Academy of Sciences · 2000 · 399 citations

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1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis

Michael S. Bernatowicz, Youling Wu, Gary R. Matsueda · The Journal of Organic Chemistry · 1992 · 334 citations

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Pharmaceutical profiling in drug discovery

Edward H. Kerns · Drug Discovery Today · 2003 · 283 citations

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