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Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistry5,5′-Disubstituted AminohydantoinsMedicineNatural SciencesRational Drug DesignPotent β-SecretaseDrug DevelopmentChemical BiologyPharmacologyMolecular ModelingInitial OptimizationDrug Discovery