Steve Jacobsen

Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors

Michael S. Malamas, Jim Erdei, Iwan Gunawan et al. · Journal of Medicinal Chemistry · 2009 · 133 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Neurofilament ELISA validation

Axel Petzold, Ayşe Altıntaş, Laura Andreoni et al. · Journal of Immunological Methods · 2009 · 105 citations · Full text

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Derek C. Cole, Eric S. Manas, Joseph R. Stock et al. · Journal of Medicinal Chemistry · 2006 · 101 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Derek C. Cole, Joseph R. Stock, Rajiv Chopra et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability

Michael S. Malamas, Albert J. Robichaud, Jim Erdei et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10