Endogenous ligands and inverse agonism

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

Richard A. Bond, Paul Leff, T. David Johnson et al. · Nature · 1995 · 421 citations

Life Sciences, Pharmacology, Physiology +12

Inverse agonist activity of beta-adrenergic antagonists.

Peter Chidiac, Terence E. Hébert, Manon Valiquette et al. · Molecular Pharmacology · 1994 · 373 citations

Medicine, Pharmacology, Cell Signaling +13

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

Graeme Milligan, Richard A. Bond, Melanie Lee · Trends in Pharmacological Sciences · 1995 · 294 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

E L Barker, Ryan S. Westphal, Dennis E. Schmidt et al. · Journal of Biological Chemistry · 1994 · 257 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

Philippe Samama, Gang Pei, Tommaso Costa et al. · Molecular Pharmacology · 1994 · 238 citations

Life Sciences, Biochemistry, Pharmacology +17